Histopathology of natural cases of PPR, characteristics, lesions and changes occurring during the disease. PPR in sheep and goats - a review. The Endocrine Pancreas 3. However, acute rinderpest can occasionally be seen in small ruminants. 226 patients with rosacea, which included 52 patients with the erythematotelangiectatic rosacea (ETR) and 174 patients with the papulopustular rosacea (PPR) subtype. It is generally accepted that pathology peer review (PPR) is an important procedure to verify and improve the accuracy and quality of histopathology data generated by the study pathologist in toxicological studies of xenobiotics including pharmaceuticals and agrochemicals with experimental animals. histopathology. https://doi.org/10.1016/j.vetmic.2016.11.006, http://www.oie.int/fr/sante-animale-dans-le-monde/portail-ppr/, https://doi.org/10.1371/journal.pone.0087145, https://doi.org/10.1111/j.1865-1682.2011.01270.x, https://doi.org/10.1007/s00705-017-3456-4, https://doi.org/10.1007/s00705-019-04269-y. Aims and Scope; Submitting your Manuscript 2.1 Submission Checklist 2.2 Article Preparation Support 2.3 Review Process 2.4 Manuscript Structure 2.5 Graphical Abstract 2.6 Submission of a Revised Version; Post-acceptance; 1. This article deals with an extensive study on histopathology of affected organs in goats by PPR virus. PPR proteins function in organelles to target specific transcripts and are involved in plant development and growth. Histopathology. Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. As most of the flocks are unvaccinated against PPR virus, so an economical antibody-based test may serve the purpose of PPR diagnosis. https://doi.org/10.3201/eid2012.140684 PPR is defined as Preyer's pinna reflex rarely. Related Pages. However, ... Fragments of organs collected for histopathology are placed in 10% formalin. 13. INTRODUCTION TO DEPARTMENT OFHISTOPATHOLOGYHistopathology is the department of clinical lab whichdeals with the study of diff types of tissuesThe department is based on following benches: Processing Gross Tissue processing Embedding,cutting,H&E … 4.6 Histopathology. 6: Libeau, G., A. Necropsy and histopathology A total of seven dead goats were collected from seven PPR-suspected flocks and routine necropsy was performed in the Department of Pathology. Vet Microbiol 197:137–141. In areas where peste des petits ruminants (PPR) is endemic, most rinderpest-like syndromes are more likely to be PPR. Key words: goats, histopathology, immunomodulation, Nigella Sativa, PPR. Author Guidelines. Below is the link to the electronic supplementary material. PPR virus isolates differ in their pathogenicity for each host, with some strains resulting in more disease in sheep than goats. Proceedings of the International Workshop, September 24-26, 1980, IITA Ibadan, Nigeria, pp: 24-26. Google Scholar, Fakri F, Embarki T, Parida S, Bamouh Z, Jazouli M, Mahapatra M, Tadlaoui K, Fassi-Fihri O, Richardson CD, Elharrak M (2016) Re-emergence of peste des petits ruminants virus in 2015 in morocco: molecular characterization and experimental infection in alpine goats. PPR is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionary Subscription will auto renew annually. Presumptive diagnosis of the disease was done on the basis of history, clinical signs, mortality pattern, postmortem and histopathological findin gs. Histopathology Histopathology refers to the microscopic examination of various forms of human tissue. Histopathology of natural cases of PPR, characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. Google Scholar, Wang Z, Bao J, Wu X, Liu Y, Li L, Liu C, Suo L, Xie Z, Zhao W, Zhang W, Yang N, Li J, Wang S, Wang J (2009) Peste des petits ruminants virus in Tibet, China. Epidemiol Infect 138:1211–1214, Mahapatra M, Sayalel K, Muniraju M, Eblate E, Fyumagwa R, Shilinde L, Mdaki M, Keyyu J, Parida S, Kock R (2015) Spillover of Peste des petits ruminants virus from domestic to wild ruminants in the serengeti ecosystem, Tanzania. Peste des petits ruminants (PPR) in sheep and goats. 53. . Whenever possible, paired sera should be taken rather than single samples. Copyright © 1998 Elsevier Science B.V. All rights reserved. Learn more about Institutional subscriptions, Banyard AC, Parida S, Batten C, Oura C, Kwiatek O, Libeau G (2010) Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control. The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. … Histopathology of natural cases of PPR, Characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. Arch Virol 164, 1997–2003 (2019). In tumors that showed a pPR, 27.1% were grade 1 tumors, 27.1% were grade 2 tumors, and 2.1% were grade 3 tumors (Table 5). Also, if there isa high profile chemical, then a PWG maybe conducted in place of a PPR. 4). ... Fragments of organs collected for histopathology are placed in 10% formalin. It is caused by a morbillivirus in the family Paramyxoviridae. : Muhammad Munir. This is a preview of subscription content, log in to check access. PubMed  PPR can be made on clinical signs, but this diagnosis is considered provisional until laboratory confirmation is ... histopathology are placed in 10% neutral buffered formalin. Papulopustular rosacea (PPR) is the classic presentation of rosacea. In this report, we describe a severe PPR outbreak in a zoo herd of Nubian ibex (Capra nubiana), causing the deaths of 2/3 of the herd. The disease has been declared a target for global eradication. The histopathology and immunohistochemistry of most of the target tissues (intestines, tongue, lungs and lymph nodes) showed positive signal for PPR … At 150 mg/kg/day, slightly greater outer hair cell loss noted than control group. pathologyevaluation (necropsyand histopathology), pathologypeerreview, and ... majordiscrepanciesorno resolution at the PPR, then a PWG maybe convened. Key words: goats, histopathology, immunomodulation, Nigella Sativa, PPR. Berkowitz, A., Avni-Magen, N., Bouznach, A. et al. Author(s) : ... see more details, histopathology histopathology Subject Category: Disciplines, Occupations and Industries see more details, postmortem examinations postmortem examinations Subject Category: Techniques, Methodologies and Equipment Sections. Since no studies with live animals were conducted in this work, an ethical approval was not required. Proceedings of the International Workshop, September 24-26, 1980, IITA Ibadan, Nigeria, pp: 24-26. Discussion. 1983 Addis Ababa, Ethiopia: International Livestock Centre for Africa. histopathology evaluation, PPR and the need for a harmonised interpretation of the terms ‘raw data’ and ‘PPR process’, Settiagounder has recently published two articles1, 2. Background. Histopathology combined with immunohistochemical staining (e.g. 4. Laboratory diagnosis of PPR a. INTRODUCTION Peste des petits ruminants (PPR), is an acute, highly contagious and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality (Balamurugan et al., 2014). PPR stands for Preyer's pinna reflex. Accepted: 29 June 2017 Histopathological features were also compared according to the severity, through subgroup analysis within each subtype group. Animal Front 4:14–20, Kinne J, Kreutzer R, Kreutzer M, Wernery U, Wohlsein P (2017) Peste des petits ruminants in Arabian wildlife. J Comp Pathol 136:111–119, Libeau G, Diallo A, Parida S (2014) Evolutionary genetics underlying the spread of peste des petits ruminants virus. immunoperoxidase) is then performed with focus on detection of multinucleated giant cells. © 2020 Springer Nature Switzerland AG. It is closely related to Rinderpest, measles, canine distemper and morbilliviruses of marine mammals and is the most economically important viral disease of small ruminants [1-3]. Looking for online definition of PPR or what PPR stands for? PubMed Google Scholar. By continuing you agree to the use of cookies. Peste des petits ruminants (PPR) is an acute or subacute viral disease of goats and sheep characterized by fever, necrotic stomatitis, gastroenteritis, pneumonia, and sometimes death. Histology. Since then, other attempts to reproduce the pathology associated with PPR have been performed under experimental conditions [13–16], however, results have varied considerably. PPR and not in RP are crusting scabs along the lips and development of pneumonia in later stages of disease. Springer-Verlag Berlin Heidelberg, pp 69–93, Abu Elzein EME, Housawi FM, Bashareek Y, Gameel AA, Al-Afaleq AI, Anderson E (2004) Severe PPR infection in gazelles kept under semi-free range conditions. Pustular lesions usually have a … Emerg Infec Dis 15:299–301, Article  PPR infection is most commonly recorded among the sheep population in India. Specifically, in clinical medicine, histopathology refers to a biopsy or surgical sample examination by a pathologist. However, the function of PPR proteins in cotton is still unknown. J Vet Med B 51:68–71, Muniraju M, Munir M, Parthiban AR, Banyard AC, Bao J, Wang Z, Ayebazibwe C, Ayelet G, El Harrak M, Mahapatra M, Libeau G, Batten C, Parida S (2014) Molecular evolution of peste des petits ruminants virus. The histopathology, IHC, and quantitative RT-PCR results from both sheep and goats also provide some insight into the disease progression of PPR in small ruminants. Rev Sci Tech 23:807–819, Truong T, Boshra H, Embury-Hyatt C, Nfon C, Gerdts V, Tikoo S, Babiuk LA, Kara P, Chetty T, Mather A, Wallace DB, Babiuk S (2014) Peste des petits ruminants virus tissue tropism and pathogenesis in sheep and goats following experimental infection. the histopathology of samples from infected animals was consistent with those found in naturally infected animals. PPR is an acute highly contagious viral disease of goats, less commonly sheep and closely related wild bovidae, and is clinically mimics cattle plague, ... For histopathology slices of lymph node, spleen, tonsils, and mucosal lesions are collected in 10 % formalin saline for. Downloadable! No single pathognomonic lesion is found that would permit certain histopathologic diagnosis of HPS. A tentative diagnosis of PPR can be made based on clinical signs, but this ... • Set of tissues for histopathology should be placed in 10% neutral buffered formalin 53. Conventional Methods of PPRV Diagnosis Histopathology of natural cases of PPR, Characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. Google Scholar, Hoffmann B, Wiesner H, Maltzan J, Mustefa R, Eschbaumer M, Arif FA, Beer M (2012) Fatalities in wild goats in kurdistan associated with peste des petits ruminants virus. Peste des petits ruminants (PPR) is an acute or subacute viral disease of goats and sheep characterized by fever, necrotic stomatitis, gastroenteritis, pneumonia, and sometimes death. Majority were grade 2 tumors out of which 81% showed pPR and 18.5% showed pCR. Ruetten PPR(1), Cluroe AD(2), Usman A(1), Priest AN(3), Gillard JH(1), Graves MJ(4). Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. Key words: goats, histopathology, immunomodulation, Nigella Sativa, PPR. Arch Virol 162:3157–3160. It was first reported in Cote d’Ivoire (the Ivory Coast) in 1942 and subsequently in other parts of West Africa. HistoPATHOLOGY 1. Vet Microbiol 22:341–352, Perl S, Alexander A, Yakobson B et al (1994) Peste des petits ruminants (PPR) of sheep in Israel. Asaf Berkowitz and Oran Erster contributed equally to this work. In fact, the incipient stages of ARDS can create a picture of pulmonary edema similar to HPS. PPR is regarded as the most economically important viral disease of small ruminants particularly goats in areas where these animals are intensively reared. Aims and Scope. An outbreak of peste des petits ruminants (PPR) in camels in the Sudan ... Histopathology Histopathologically, the bronchioles showed degeneration and denudation of the epithelium and peribronchial infiltration of mononuclear cell (Fig. Peste des petits ruminants (PPR) is a devastating disease that generally affects sheep and goats, mostly in Asia, the Middle East and Africa. Histopathology of natural cases of PPR, characteristic lesions and changes occurring during the disease peste des petits ruminants (PPR) in sheep and goats. 5. When PPR is suspected, laboratory diagnostic testing will be performed at the National Veterinary Services Laboratories, Foreign Animal Disease Diagnostic Laboratory (NVSL FADDL) at Plum Island, NY. 1983 Addis Ababa, Ethiopia: International Livestock Centre for Africa. Histopathology - Definition it is a branch of pathology which deals with the study of disease in a tissue section. Histopathological examination of tissues starts with surgery, biopsy or autopsy. It was first reported in Cote d’Ivoire (the Ivory Coast) in 1942 and subsequently in other parts of West Africa. Further molecular examination showed that the virus belongs to the Asian clade of lineage IV and is closely related to a virus described in Turkey. CAS  Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The disease has been declared a target for global eradication. PPR is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms The Free Dictionary (PMID: 25418782), Taylor WP, Albusaidy S, Barrett T (1990) The Epidemiology of peste-des-petits-ruminants in the sultanate of Oman. Following the first description of PPR it was postulated that the causal agent was a variant strain of rinderpest adapted to small ruminants (Mornet et al., 1956).This was confirmed by the present knowledge on the epidemiology of the two diseases which occur separately … The endocrine cells of the pancreas are localized in the islets of Langerhans and constitute only 2% of the mass of the pancreas. https://doi.org/10.1371/journal.pone.0087145, Article  Isr J Vet Med 49:49–59, Furley CW, Taylor WP, Obi TU (1987) An outbreak of peste des petits ruminants in a zoological collection. OVERVIEW OF HISTOPATHOLOGYBYSEEMA DEROTRANIEE TECHNOLOGIST 2. Part of Springer Nature. Copyright © 2020 Elsevier B.V. or its licensors or contributors. At the end of the outbreak, blood can be collected for serological diagnosis. Histopathology combined with immunohistochemical staining (e.g. volume 164, pages1997–2003(2019)Cite this article. PubMed Central  Papulopustular rosacea (PPR) is the classic presentation of rosacea. Correspondence to The first article covered the inconsistencies and controversies that have prevailed during the last three decades regarding the term ‘raw data’ as applied Emerg Infect Dis 21:2230–2234, Shatar M, Khanui B, Purevtseren D, Khishgee B, Loitsch A, Unger H, Settypalli TBK, Cattoli G, Damdinjav B, Dundon WG (2017) First genetic characterization of peste des petits ruminants virus from Mongolia. Present address: Central Virology Laboratory, Israeli Ministry of Health, Sheba Medical Center, 5266202, Ramat Gan, Israel. For some diseases, th… Reduction of Ppr expression to very low levels prevented mammary gland development. immunoperoxidase) is a useful procedure because it is performed on formalin-fixed material and can discriminate between PPR and rinderpest when performed with specific monoclonal antibodies. Oran Erster. In a fully susceptible population, as is thecase in non-endemic areas, morbidity andmortality can approach 100 percent. Division of Pathology, Kimron Veterinary Institute, Bet Dagan, 50250, Israel, Division of virology, Kimron Veterinary Institute, 50250, Bet Dagan, Israel, Orly Friedgut, Velizar Bombarov, Marisol Guini-Rubinstein, Yehuda Stram, Avi Eldar & Oran Erster, Biblical zoo of Jerusalem, Derech Aharon Shulov 3, Jerusalem, Israel, Veterinary Clinic, 9 Meginay Hagalil Street, Rehovot, Israel, You can also search for this author in This study revealed peculiar findings such as severe affection of respiratory system with mild involvement of alimentary system that was seen to be rare and exclusively to Indian outbreaks of PPR. Accepted: 29 June 2017 Pathological and molecular characterisation of peste des petits ruminants in Nubian ibex (Capra nubiana) in Israel. We use cookies to help provide and enhance our service and tailor content and ads. 18. endocrine pancreas 1. In both species, significant levels of virus were detected in the lymph nodes, lymphoid tissues and digestive tract at 6 dpi. A less‐severe reduction in Ppr expression permitted progression of mammary gland development beyond the induction stage, but the nipples of these mice were dramatically smaller than those of controls, with altered epidermis and connective tissue. Recognition of PPR as a problem has increased in the 1990s, partly as a result of surveillance activities of the global rinderpest eradication programme (GREP), but also because of the capacity of the infection to invade disease-free countries. A tentative diagnosis of PPR can be made based on clinical signs, but this diagnosis is ... • Set of tissues for histopathology should be placed in 10% neutral buffered formalin It is then processed and cut into very thin layers (called sections), stained, and examined under microscopes to characterize the details of the cells in the tissue. Out of the 21 cases of grade 1 tumors 66.7% showed pPR and 33% showed pCR. • They not only establish tissue diagnosis, but are crucial in clinical management & provide important prognostic data. The tissue undergoes a series of steps before it reaches the examiners desk to be thoroughly examined microscopically to arrive at a particular diagnosis. This is likely due to variations in Looking for online definition of PPR or what PPR stands for? This is likely due to variations in https://doi.org/10.1007/s00705-017-3456-4. However, the function of PPR proteins in cotton is still unknown. • Histopathology specimens are a vital in patient care. Histology Lectures; Powerpoint Presentations and Tutorials for medical students by Dr. Mohammad Kasem Rinderpest, or cattle plague, is an acute, highlycontagious viral disease of wild and domesticatedruminants and pigs. https://doi.org/10.1111/j.1865-1682.2011.01270.x, Banyard AC, Parida S (2015) Molecular epidemiology of peste des petits ruminants virus. https://doi.org/10.1016/S0921-4488(97)00095-3. Ed. PPR is often rendered more severe by secondary bacterial infections, concomitant helminthiasis, INTRODUCTION Peste des petits ruminants (PPR), is an acute, highly contagious and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality (Balamurugan et al., 2014). Results: … affected animals were vaccinated against PPR. The disease has been declared a target for global eradication. PPR and not in RP are crusting scabs along the lips and development of pneumonia in later stages of disease. Withsome strains of the virus, however, the diseasemay be mild with low mortality frominfection. CAS  Emerg Infect Dis 20:2023–33. In the regions where PPR occurs in an epizootic form it may have dramatic consequences for animal owners due to high mortality rates. Archives of Virology The frequency of each histopathological finding was compared between subtypes. Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. https://doi.org/10.1016/j.vetmic.2016.11.006, OIE: The OIE official info http://www.oie.int/fr/sante-animale-dans-le-monde/portail-ppr/. 14. D.H Hill (eds) ILCA Addis Ababa. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease. It is good practice to collect blood for serological diagnosis at all stages, but particularly later in the outbreak. This article deals with the first exclusive outbreak of PPR in goats in a mixed population that occurred in the southern districts of Tamilnadu, India. immunoperoxidase) is a useful procedure because it is performed on formalin-fixed material and can discriminate between PPR and rinderpest when performed with specific monoclonal antibodies. Peste des petits ruminants (PPR) is a highly contagious viral disease of goats and sheep. Background: The pentatricopeptide repeat (PPR) gene family, which contains multiple 35-amino acid repeats, constitutes one of the largest gene families in plants. The flock of sheep including 800 fattening sheep were affected and the presence of PPR virus was assayed with RT-PCR test. However, the total picture is rather distinctive. The diagnosis of PPR virus infection both in natural outbreak and experimental cases were based on clinical signs, gross pathology, histopathology and ELISA test for confirmation of the PPR virus. The clinical onset was acute with morbid animals exhibiting lethargy and watery-to-bloody diarrhea and death usually within 48 h. The most consistent gross pathologic findings were hemorrhagic abomasitis and enteritis. The tissue that is studied comes from a biopsy or surgical procedure whereby a sample of the suspect tissue is selected and sent to the laboratory. Peste des petits ruminants virus. The alveolar septa was congested and affected animals were vaccinated against PPR. Mesenteric lymph node -PCR PPR ha s become endemic in the country and Outbreak, PPR, Goats, ELISA, RT-PCR. This study was funded by internal resources of the Kimron Institute. histopathology is the only way to diagnose infections caused by L. loboi or Rhinosporidium seeberi [Figure 2] as cultivation techniques have to date been unsuccessful. Proceedings of the International workshop held at IITA Ibadan, Nigeria, 24-26 September. All the outbreaks recorded revealed no sex differences but the age of susceptibility was seen much in young ones and death was more noted in them. The histopathological aspect of the infection in various organs has been studied in correlation with the clinical signs and symptoms from materials collected in 10 different outbreaks of PPR in goats. Immediate online access to all issues from 2019. Molecular examinations confirmed the diagnosis of PPR and determined that the causative agent belongs to lineage IV. It is characterized bysudden onset of fever, oculonasal discharges,necrotic stomatitis, gastroenteritis and death. To achieve this it is important that the tissue must be prepared in such a Histology revealed necrohemorrhagic enteritis and abomasitis with myriad nuclear and cytoplasmic viral inclusion bodies. . Histopathology of natural cases of PPR, characteristics, lesions and changes occurring during the disease. Peste des Petits Ruminants (PPR), also known as Goat Plague and Ovine Rinderpest, occurs in goats, sheep and related species. PPR is a disease of high morbidity and mortality that affect small ruminants reared by poor and marginal farmers of India. Fragments of organs collected for histopathology are placed in 10% formalin. Department has modern histopathology, cytopathology, haematology and service laboratories for catering the needs of Mahatma Gandhi Hospital attached to the medical college. Despite its high prevalence in domestic flocks and its high seroprevalence among wildlife, it is rarely reported as a fulminant disease in wild ruminant species (with the exception of Central Asia).